If the finding can be validated by larger studies, fusobacterium might one day be used to prevent and screen for colorectal cancer, currently detectable through colonoscopy or tests for the presence of blood in the stool. fuscobacterium also might play a role in determining the prognosis of colorectal cancers and shaping their treatment, according to two research teams independently reporting a relationship between the rod-shaped microbe and cancers of the lower digestive system.

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Times Record News (Wichita Falls, Texas)

March 27, 2011

St. Petersburg Times

If you’ve been putting of f that visit to the dentist, figuring if you don’t have a toothache there’s nothing to worry about, think again. In addition to watching out for your teeth and gums, dentists also look for oral cancers and other health conditions that may announce themselves in your mouth. A growing body of scientific evidence suggests there is a link between dental health and heart disease. That’s one reason why your dentist may prescribe aggressive treatment for gum disease, or even send you to the cardiologist.

St. Petersburg, Fla., dentist John Ferullo is among those who think the link is strong enough to warrant screening some patients with gum disease for a blood protein called CRP. High levels of C-reactive protein are associated with increased heart-attack and stroke risk, though exactly how they’re linked isn’t fully understood. The screening, which he gives to patients whose gums are swollen and bleed easily, is a simple fingerprick blood test. “Five years ago, people wouldn’t have been open to it,” Ferullo said. “But now, because they’ve seen it on TV shows like ‘Oprah’ and ‘Dr. Oz,’ they are receptive to the idea and the screening.”

In the past 20 to 25 years, a number of studies published in major medical journals have looked at the connection between gum disease, heart disease and stroke. One theory is that bacteria in the mouth can get into the bloodstream and travel to plaque deposits in the arteries. That can cause the deposits to become swollen and unstable, and more likely to rupture and cause a heart attack or stroke. The same bacteria found in the mouth have been found attached to plaques in the arteries. (But dental plaque and arterial plaque are two different things.) Dental bacteria may also trigger blood cells to swell and arteries to narrow, which can impede blood flow.

While the finger-prick test Ferullo uses, known as an hs-CRP test, can detect inflammation in the body, it can’t tell precisely where it’s occurring. It might be in any number of places, such as the arteries or gums, or due to diseases like arthritis or inflammatory bowel disease. Ferullo thinks in-office screening may narrow the field of possible causes. “If after aggressive treatment (for gum disease) they still have elevated CRP, we refer them back to their physician because something else is definitely going on,” he said. A spokesman for the Florida Dental Association, Tampa dentist Terry Buckenheimer, said the CRP screening is not considered standard practice because CRP can be elevated by many causes. “But that’s not to say it’s not right” to screen, he said. “It might save a life, and that has value.”

An American Academy of Periodontology spokesman said most dentists aren’t doing this screening, though it’s likely the practice will increase in coming years. But Dr. Patrick Cambier, an interventional cardiologist with Morton Plant Hospital in Clearwater, Fla., says that like all screening tests, this one needs to be approached with caution. Scientists long have been looking for markers in the blood to detect heart disease, and CRP has gotten a lot of attention. While it may detect inflammation in the blood vessels associated with atherosclerosis, the test doesn’t tell doctors if those plaques are likely to rupture and cause heart attacks or stroke. “We have to be cautious about screening for the sake of screening,” he said. “It is costly, can lead to false positives, more tests, more cost and more anxiety for patients.”

While scientists sort it all out, it’s important to follow a heart-healthy lifestyle: Exercise, maintain a healthy weight, don’t smoke, eat right and watch cholesterol, blood pressure and diabetes.

http://www.joslin.org/info/Dental_Health_and_Diabetes.html